Peer Review of the Integrated Risk Information System (IRIS) Toxicological Review of Hexavalent Chromium


EPA’s Office of Research and Development has requested that the SAB review the draft EPA IRIS Toxicological Review of Hexavalent Chromium. The draft assessment includes a hazard identification analysis, which summarizes the chemical properties, toxicokinetics, and health effects associated exposure, and dose-response analysis, which characterizes the quantitative relationship between chemical exposure and each credible health hazard. These quantitative relationships are used to derive cancer and non-cancer toxicity values (e.g., inhalation unit risk, oral slope factor, reference concentration, reference dose).

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